An experimental Parkinson’s drug missed its primary goal in a mid-stage trial, Roche said, in what is the second setback this week for candidate treatments for the neurodegenerative condition.

The action comes over contract negotiations and the company’s refusal to recognize the Teamsters labor union.

Dollar Tree said it has named Michael Creedon Jr. as the discount retailer’s permanent chief executive, removing the interim tag he has carried since early November.

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